Large scale screening for hemoglobinopathies, utilizing electrophoresis.
نویسندگان
چکیده
منابع مشابه
Comparison of capillary electrophoresis with cellulose acetate electrophoresis for the screening of hemoglobinopathies.
BACKGROUND β-thalassemia is primarily found in individuals of Mediterranean and Southeast Asian ancestry. With rapid growth in the Southeast Asian segments of the Korean population, the geographic distribution of hemoglobinopathies is expected to become significantly different from what it is today. In this study, Hb fractions were measured in patients with hypochromic microcytosis to detect th...
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OBJECTIVES To analyze the results of hemoglobin electrophoresis (HE) in the routine laboratory of a tertiary hospital in Kuwait and to review the common types of hemoglobinopathies prevalent in the country. METHODS This was a prospective study of HE performed on 2,386 samples in Mubarak Al-Kabeer Hospital, which serves more than 30% of the population of Kuwait, from June 1997 to May 1998. R...
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BACKGROUND Newborn screening (NBS) for hemoglobinopathies facilitates early identification of affected individuals to ensure the prompt institution of comprehensive medical care for affected newborns in California. When linked to extensive follow-up and education, NBS has been shown to significantly reduce mortality in children with sickle cell disease. Due to changing immigration patterns from...
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nificant lengthening of PFS was the result of IFN maintenance therapy, as already reported.10 Our experience, although limited, confirms the efficacy of purine analogs as second line therapy. In agreement with Rai et al.8 the very high projected survival probability of our series can be explained mainly by a two step therapeutic strategy made up of IFN first line therapy and purine analog salva...
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The hemoglobinopathies encompass a heterogeneous group of disorders associated with mutations in both the alpha-globin and beta-globin genes. Non-sickling disorders are found primarily in individuals of Mediterranean, Asian and Southeast Asian ancestry. With rapid growth in the Asian and Hispanic segments of the US population, the geographic distribution of hemoglobinopathies is expected to bec...
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ژورنال
عنوان ژورنال: American Journal of Public Health
سال: 1974
ISSN: 0090-0036,1541-0048
DOI: 10.2105/ajph.64.10.993